Meclizine hydrochloride (25 mg/1) + Dimethicone (125 mg/1) + Doxylamine succinate (25 mg/1) + Ibuprofen (200 mg/1) + Loperamide hydrochloride (2 mg/1)Ĭategories ATC Codes R06AE55 - Meclozine, combinationsĬhemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as diphenylmethanes. Meclizine hydrochloride (25 mg/1) + Acetaminophen (325 mg/1) + Acetaminophen (500 mg/1) + Bacitracin zinc (400 /1g) + Benzalkonium chloride (1.3 mg/1g) + Benzocaine (200 mg/1g) + Bismuth subsalicylate (262 mg/1) + Calcium carbonate (420 mg/1) + Calcium carbonate (27 mg/1) + Dextromethorphan hydrobromide monohydrate (15 mg/1) + Diphenhydramine hydrochloride (25 mg/1) + Guaifenesin (200 mg/1) + Hydrocortisone acetate (10 mg/1g) + Ibuprofen (200 mg/1) + Lidocaine hydrochloride (5 mg/1g) + Loratadine (10 mg/1) + Magnesium oxide (20 mg/1) + Neomycin sulfate (3.5 mg/1g) + Phenylephrine hydrochloride (5 mg/1) + Polymyxin B sulfate (5000 /1g) + Potassium chloride (80 mg/1)Ĭream Kit Liquid Ointment Tablet Tablet, chewable Tablet, film coated Meclizine hydrochloride (12.5 mg) + Niacin (50 mg)
Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc NCS HealthCare of KY, Inc dba Vangard Labs Previous Next International/Other Brands Chiclida / Meclicot / Navicalm / Nevidoxine / Postafen / Sea-Legs Brand Name Prescription Products Nameĭenton Pharma, Inc. The risk or severity of adverse effects can be increased when Meclizine is combined with Agomelatine. The metabolism of Meclizine can be increased when combined with Adalimumab. Meclizine may increase the central nervous system depressant (CNS depressant) activities of Aclidinium. The risk or severity of adverse effects can be increased when Meclizine is combined with Acetophenazine. The risk or severity of adverse effects can be increased when Meclizine is combined with Acetazolamide. The metabolism of Meclizine can be decreased when combined with Acetaminophen.
The metabolism of Meclizine can be decreased when combined with Acebutolol. The metabolism of Meclizine can be decreased when combined with Abiraterone. The metabolism of Meclizine can be increased when combined with Abatacept. The risk or severity of adverse effects can be increased when Meclizine is combined with 1,2-Benzodiazepine. 1 Meclizine may also decrease the labyrinth excitability and vestibular stimulation. Through its antagonistic action on the H1 receptors, meclizine primarily works by inhibiting signaling pathway transduction through histaminergic neurotransmission from the vestibular nuclei and NTS to the CTZ and medullary vomiting center. When activated, H1 receptor signaling from these nuclei is transmitted to the CTZ and vomiting centre. Histamine H1 receptors are expressed on the vestibular nuclei and nucleus of the solitary tract (NTS) that are activated by motion sickness and stimuli from the pharynx and stomach. Different receptors responding to different factors, including histamine, 5-HT, enkephalins, substance P, and dopamine, are expressed along the brainstem to activate respective pathways and contribute to the control of vomiting. The blood-brain barrier near the CTZ is relatively permeable to circulating mediators and CTZ can transmit impulses to vomiting center located in the brainstem. Motion sickness is also regulated by CTZ. Vomiting is a centrally regulated reflex mechanism that initiates from the vomiting center and the chemoreceptor trigger zone (CTZ) located in the medulla. 4 Meclizine is reported to cause drowsiness due to its anticholinergic actions. The onset of action of meclizine is about 1 hour, with effects lasting between 8 to 24 hours. It is effective against nausea and vomiting arising from many causes, including motion sickness and disorders affecting the vestibular system. Meclizine works on the higher centres of the brain to reduce nausea, vomiting, or vertigo.
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